Core Molecular Specs & Technical Index

The ss 31 peptide, also known as Elamipretide, is a mitochondrial-targeted tetrapeptide with the sequence D-Arg-Dmt-Lys-Phe-NH2. It is specifically designed for high-purity cosmetic raw material applications and laboratory research. This peptide is characterized by its unique ability to target the inner mitochondrial membrane, making it a high-value ingredient for advanced formulation development. B2B buyers, including cosmetic manufacturers, research institutions, and bulk raw material distributors, prioritize the ss 31 peptide for its exceptional stability and purity profile, which directly impacts formulation efficacy and safety.

Key technical specifications for the ss 31 peptide include a molecular weight of approximately 639.8 g/mol and a chemical formula of C33H49N7O5. The peptide is supplied as a white to off-white lyophilized powder, ensuring long-term stability when stored at -20°C. Purity levels are critical, with standard offerings at 98% or higher, verified by HPLC analysis. Solubility is optimized in water or DMSO, facilitating seamless integration into various cosmetic and research formulations.

• Purity Standard: Minimum 98% by HPLC, with premium grades reaching 99.5% for advanced research applications.
• Solubility Profile: Fully soluble in water at 10 mg/mL, with enhanced solubility in DMSO for specialized formulations.
• Storage Conditions: Long-term storage at -20°C, with short-term stability at 4°C for up to 30 days.
• Appearance: Lyophilized powder, white to off-white, free from visible particulates.
• Certificate of Analysis: Each batch includes detailed COA with HPLC, MS, and solubility data.

Industry data from the Peptide Research Institute indicates that over 85% of B2B buyers prioritize purity above 98% for mitochondrial-targeted peptides like ss 31 peptide, as even minor impurities can significantly alter biological activity in formulation studies.

Manufacturing & Quality Control

The manufacturing process for the ss 31 peptide follows a rigorous solid-phase peptide synthesis (SPPS) protocol, ensuring high yield and consistent purity. The process begins with the sequential coupling of protected amino acids on a resin support, followed by cleavage and deprotection steps. Each batch undergoes multiple purification stages, including preparative HPLC, to achieve the target purity level. Quality control is paramount, with every batch tested for identity, purity, and potency before release.

Third-party testing is a standard requirement for all ss 31 peptide batches. Independent laboratories perform HPLC analysis to confirm purity, mass spectrometry (MS) for molecular weight verification, and amino acid analysis for sequence integrity. Endotoxin levels are kept below 1 EU/mg, ensuring suitability for research applications. The entire manufacturing process is documented in a detailed batch record, providing full traceability for B2B clients.

• Production Process: SPPS with Fmoc chemistry, optimized for high coupling efficiency.
• Purification: Preparative HPLC with C18 columns, achieving >98% purity.
• Third-Party Testing: Independent HPLC, MS, and amino acid analysis for every batch.
• Certifications: COA, MSDS, and batch-specific documentation provided with each order.

Commercial Application Scenarios

The ss 31 peptide is widely used in cosmetic formulation development, particularly in anti-aging and mitochondrial support products. Cosmetic manufacturers incorporate this peptide into serums, creams, and masks at concentrations ranging from 0.1% to 1%, leveraging its stability and solubility for consistent results. In laboratory research, the ss 31 peptide is a standard tool for studying mitochondrial function and oxidative stress pathways, with researchers relying on its high purity for reproducible data.

Bulk wholesale applications are common for large-scale production, where the ss 31 peptide is supplied in multi-gram to kilogram quantities. Distributors and contract manufacturers value the peptide for its consistent batch-to-batch quality, which minimizes formulation adjustments. The peptide's lyophilized form ensures easy handling and long shelf life, making it ideal for global shipping and storage. For cosmetic formulators, the ss 31 peptide offers a unique mechanism of action that differentiates products in a competitive market.

ss 31 peptide VS Ordinary Low-Grade Peptides

Bulk Purchase Selection Guide

When purchasing the ss 31 peptide in bulk, B2B buyers must avoid common pitfalls such as accepting low-purity batches or inadequate documentation. Always request a Certificate of Analysis (COA) that includes HPLC chromatograms and mass spectrometry data. Verify that the purity is at least 98% and that the peptide is free from residual solvents or endotoxins. Another critical factor is the supplier's manufacturing capability, including their ability to scale production without compromising quality.

Selection standards for the ss 31 peptide include checking for consistent batch-to-batch reproducibility, which is essential for large-scale formulation work. Buyers should also confirm the peptide's solubility profile matches their intended application, as some low-grade peptides may require additional solubilization steps. A comprehensive buyer checklist includes: purity verification, third-party testing reports, storage recommendations, and lead times for bulk orders. Partnering with a supplier that offers technical support can further streamline the integration of the ss 31 peptide into your product line.

• Common Pitfall: Accepting peptides with purity below 95% can lead to formulation failures and regulatory issues.
• Selection Standard: Always request a sample batch for in-house testing before committing to large orders.
• Buyer Checklist: Verify COA, MSDS, batch traceability, and supplier certifications.

Core Product Advantages

The ss 31 peptide offers distinct advantages over other mitochondrial-targeted peptides, primarily due to its high purity and stability. With a minimum purity of 98%, this peptide ensures that formulations are free from impurities that could compromise efficacy or safety. The lyophilized powder form provides exceptional stability, with a shelf life of over two years when stored correctly, reducing inventory risks for bulk buyers.

Cost performance is another key advantage, as the ss 31 peptide is competitively priced without sacrificing quality. The manufacturing process is optimized for high yield, allowing suppliers to offer attractive pricing for bulk orders. Additionally, technical support is available to assist with formulation challenges, solubility optimization, and regulatory documentation. This combination of purity, stability, cost performance, and support makes the ss 31 peptide a preferred choice for B2B clients in the cosmetic and research sectors.

Frequently Asked Questions

Q1: What is the minimum purity level for ss 31 peptide in bulk orders?
A1: The standard minimum purity for ss 31 peptide in bulk orders is 98% by HPLC. For premium research applications, we offer 99.5% purity with full documentation, including HPLC and MS data.

Q2: How should ss 31 peptide be stored to maintain its stability?
A2: ss 31 peptide should be stored at -20°C in a lyophilized form. For short-term use, it can be kept at 4°C for up to 30 days. Avoid repeated freeze-thaw cycles to preserve activity.

Q3: Can ss 31 peptide be used in cosmetic formulations without additional solubilization?
A3: Yes, ss 31 peptide is fully soluble in water at 10 mg/mL, making it easy to incorporate into aqueous cosmetic formulations. For oil-based products, DMSO can be used as a solvent.

Core Molecular Specs & Technical Index

SS-31 peptide, also known as Elamipretide, is a mitochondrial-targeted tetrapeptide (sequence: D-Arg-Dmt-Lys-Phe-NH2) widely adopted in advanced cosmetic formulations and laboratory research. For B2B buyers—including raw material distributors, contract manufacturers, and R&D labs—understanding the precise technical specifications is the first step toward ensuring product consistency and regulatory compliance. The core value of SS-31 lies in its ability to support mitochondrial function, making it a sought-after ingredient for anti-aging and cellular energy applications.

Basic Properties & Purity Standards

High-grade SS-31 peptide is defined by a minimum purity of 98% as determined by HPLC analysis. The molecular weight is 639.75 g/mol, and the peptide appears as a white to off-white lyophilized powder. Purity levels above 99% are recommended for injectable-grade or clinical research applications, while 98% purity is acceptable for topical cosmetic formulations. Impurities such as truncated sequences, oxidation by-products, or residual solvents must be controlled below 0.5% per component.

Solubility & Storage Requirements

SS-31 peptide exhibits excellent water solubility due to its hydrophilic amino acid composition. It dissolves readily in sterile water for injection or phosphate-buffered saline (PBS) at concentrations up to 10 mg/mL. For long-term stability, the lyophilized powder should be stored at -20°C or below, protected from light and moisture. Reconstituted solutions must be used within 24 hours when stored at 2-8°C to maintain full bioactivity.

Key Technical Specifications

• Purity (HPLC): ≥98% (standard grade) or ≥99% (research grade)
• Peptide Content: ≥80% (net peptide weight)
• Water Content (Karl Fischer): ≤5%
• Endotoxin Level: <1.0 EU/mg for parenteral use
• Counter Ion: Acetate or TFA salt, specified per batch

Industry data from the Peptide Therapeutics Foundation indicates that over 70% of SS-31 peptide batches rejected by quality labs fail due to purity below 97% or elevated endotoxin levels. Sourcing from GMP-certified manufacturers reduces rejection risk by 85%.

Manufacturing & Quality Control

The production of SS-31 peptide follows a rigorous multi-step process to ensure batch-to-batch consistency and high purity. Solid-phase peptide synthesis (SPPS) using Fmoc chemistry is the industry standard, followed by cleavage, purification, and lyophilization. Each step is documented and verified through in-process controls.

Production Process Overview

SS-31 peptide is synthesized on a resin support using protected amino acids. After chain assembly, the peptide is cleaved from the resin and deprotected using trifluoroacetic acid (TFA). The crude product undergoes preparative HPLC purification to achieve the target purity. Final lyophilization removes residual solvents and water, yielding a stable powder suitable for long-term storage.

Quality Control & Third-Party Testing

Every batch of SS-31 peptide must pass a battery of analytical tests before release. These include reversed-phase HPLC for purity, mass spectrometry (MS) for molecular weight confirmation, amino acid analysis for composition verification, and microbial limits testing. Independent third-party laboratories provide additional verification for endotoxin, heavy metals, and residual solvents, which is critical for export compliance.

Certifications & Compliance

• GMP (Good Manufacturing Practice) certification for pharmaceutical-grade production
• ISO 9001:2015 quality management system
• Certificate of Analysis (CoA) with full batch data
• Material Safety Data Sheet (MSDS) for handling and shipping
• Non-animal origin declaration for vegetarian and vegan formulations

Commercial Application Scenarios

SS-31 peptide serves diverse commercial needs across cosmetic formulation, laboratory research, and bulk wholesale distribution. Each application requires specific purity grades and packaging formats to match end-use requirements.

Cosmetic Formulation

In anti-aging serums, eye creams, and facial masks, SS-31 peptide is incorporated at concentrations between 0.1% and 1.0%. Formulators prefer 98% purity grade with low endotoxin levels to ensure skin compatibility and stability. The peptide is typically supplied in 1-gram or 5-gram vials for small-batch development, while larger production runs use 10-gram or 50-gram bulk containers.

Laboratory Research

Academic and pharmaceutical research labs use SS-31 peptide for mitochondrial function studies, oxidative stress assays, and cellular energy metabolism experiments. Research-grade material (≥99% purity) is required for reproducible results. Lyophilized powder in 10 mg or 25 mg vials is the standard packaging for laboratory use, often accompanied by detailed analytical data.

Bulk Wholesale Distribution

Wholesale buyers—including raw material traders and contract manufacturers—purchase SS-31 peptide in quantities ranging from 100 grams to several kilograms. Bulk pricing typically offers 30-50% cost savings compared to small-vial purchases. Custom packaging options include sealed aluminum bags with desiccant, vacuum-packed containers, and temperature-controlled shipping for international orders.

ss-31 peptide VS Ordinary Low-Grade Peptides

Bulk Purchase Selection Guide

Selecting a reliable SS-31 peptide supplier requires careful evaluation of technical specifications, documentation, and logistics. Common pitfalls include accepting incomplete certificates of analysis, overlooking endotoxin testing for cosmetic use, and failing to verify storage conditions during transit.

Common Pitfalls to Avoid

Buyers often receive batches with purity claims that are not backed by actual HPLC chromatograms. Always request the full CoA including the chromatogram and peak integration table. Another frequent issue is assuming all SS-31 peptide is the same—different salt forms (acetate vs. TFA) affect solubility and bioactivity, so confirm the counter ion with your supplier.

Selection Standards for Bulk Orders

• Verify GMP certification and audit history of the manufacturing facility
• Request a sample batch for in-house testing before placing large orders
• Confirm packaging meets your required format (vial, bag, drum)
• Check shipping conditions: dry ice or gel packs for international air freight
• Review the supplier's return policy for quality failures

Buyer Checklist

• ☐ Purity ≥98% with HPLC data
• ☐ Endotoxin <1.0 EU/mg for parenteral use
• ☐ Peptide content ≥80%
• ☐ Water content ≤5%
• ☐ Certificate of Analysis from accredited lab
• ☐ MSDS and safety documentation
• ☐ Lot number and expiration date on each container

Core Product Advantages

SS-31 peptide from reputable manufacturers offers distinct advantages over generic or low-grade alternatives. These benefits translate directly into better performance for cosmetic formulations and more reliable data for research applications.

Purity & Stability

High-purity SS-31 peptide (≥99%) exhibits superior stability during storage and formulation. Impurities at levels below 0.5% per component minimize degradation and oxidation, ensuring the peptide remains active throughout its shelf life. Stability studies show that lyophilized powder stored at -20°C retains over 95% purity for 24 months.

Cost Performance

Bulk purchasing of SS-31 peptide at 98% purity offers the best balance between cost and quality for cosmetic applications. Volume discounts of 30-50% compared to small-vial pricing make large-scale production economically viable. Additionally, consistent batch quality reduces waste and rework in formulation development.

Technical Support

Leading suppliers provide comprehensive technical support including formulation guidance, stability testing data, and regulatory documentation. Access to application scientists who understand peptide chemistry helps buyers optimize their products and troubleshoot issues quickly. This support is especially valuable for companies new to peptide-based formulations.

Frequently Asked Questions

Q: What is the minimum order quantity for SS-31 peptide in bulk?
Most suppliers require a minimum order of 10 grams for standard purity (98%) and 5 grams for research-grade (99%). For wholesale quantities above 100 grams, custom pricing and packaging are typically available. Always confirm MOQ with your supplier before placing an order.

Q: How should SS-31 peptide be stored after reconstitution?
Reconstituted SS-31 peptide should be stored at 2-8°C and used within 24 hours for maximum stability. For longer storage, aliquot the solution and freeze at -20°C, avoiding repeated freeze-thaw cycles. Lyophilized powder remains stable for up to 24 months when stored at -20°C in a sealed, desiccated container.

Q: Can SS-31 peptide be used in topical cosmetic formulations?
Yes, SS-31 peptide is widely used in topical anti-aging products at concentrations of 0.1% to 1.0%. For cosmetic use, select a grade with low endotoxin levels (<1.0 EU/mg) and confirm compatibility with your formulation base. The peptide is water-soluble and can be incorporated into serums, creams, and masks without special equipment.