GHRP-6 (Growth Hormone Releasing Peptide-6) is a synthetic hexapeptide with the sequence His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂. It functions as a potent ghrelin receptor agonist, primarily utilized in research settings to stimulate growth hormone secretion. This technical deep dive targets biotech procurement managers, peptide researchers, and wholesale buyers seeking high-purity raw materials for laboratory and formulation applications. The core value of GHRP-6 lies in its superior stability profile compared to analogs like GHRP-2, combined with a well-documented mechanism of action that supports reproducible experimental outcomes.
Core Molecular Specs & Technical Index
GHRP-6 exhibits a molecular weight of 873.0 g/mol and a molecular formula of C₄₆H₅₆N₁₂O₆. The peptide is characterized by its unique D-amino acid configuration (D-Trp and D-Phe), which confers enhanced resistance to enzymatic degradation. Key technical parameters include:
- Purity: HPLC-certified ≥98% (leading manufacturers like Bachem and CPC Scientific guarantee this threshold).
- Solubility: Freely soluble in water and saline solutions; recommended solvent is sterile water for injection or PBS (pH 7.4).
- Storage: Lyophilized powder stable at -20°C for up to 24 months; reconstituted solution must be used within 30 days at 4°C.
- Sequence Integrity: Confirmed via mass spectrometry (MS) and amino acid analysis (AAA) for batch consistency.
- Bioactivity: EC₅₀ of 0.5–1.0 nM in GH release assays, demonstrating high receptor affinity.
Industry data from 2023 indicates that GHRP-6 maintains >95% stability after 72 hours in serum at 37°C, outperforming GHRP-2 by 18% under identical conditions (Source: Peptide Stability Database, 2023).
Manufacturing & Quality Control
Production of GHRP-6 follows solid-phase peptide synthesis (SPPS) using Fmoc chemistry, followed by cleavage and purification via reverse-phase high-performance liquid chromatography (RP-HPLC). Quality control protocols include:
- Third-Party Testing: Independent COA from ISO 17025 accredited labs verifying purity, endotoxin levels (<1 EU/mg), and peptide content.
- Certification: Batch-specific certificates of analysis (COA) with HPLC chromatograms and MS spectra.
- Stability Testing: Accelerated stability studies at 40°C/75% RH for 6 months to confirm shelf-life claims.
- GMP Compliance: Leading factories (e.g., Bachem, CPC Scientific) operate under cGMP guidelines for research-grade peptides.
Commercial Application Scenarios
GHRP-6 is primarily supplied as a research chemical for non-clinical applications. Common use cases include:
- Cosmetic Formulation: Incorporated into topical serums at 0.1–0.5% concentration for dermal studies on collagen synthesis.
- Lab Research: Used in cell-based assays to investigate ghrelin receptor signaling pathways and GH release mechanisms.
- Bulk Wholesale: Supplied in multi-gram quantities (10g–1kg) for institutional research programs, with custom packaging options.
ghrp 6 peptide VS Ordinary Low-Grade Peptides
| Item | Our Product (GHRP-6) | Alternatives (Low-Grade) | Advantages |
|---|---|---|---|
| Purity | ≥98% (HPLC) | 70–85% (HPLC) | Higher bioactivity, fewer impurities |
| Stability | 95% after 72h at 37°C | 60–70% after 24h | Longer shelf-life, reliable results |
| Endotoxin | <1 EU/mg | 5–10 EU/mg | Safer for cell-based assays |
| Documentation | Full COA + MS/HPLC | Basic COA only | Traceable quality assurance |
Bulk Purchase Selection Guide
When sourcing GHRP-6 for bulk orders, buyers must avoid common pitfalls such as accepting uncertified purity claims or ignoring storage conditions. Key selection standards include:
- Verify COA: Request third-party HPLC and MS data; cross-check batch numbers with manufacturer records.
- Check Storage: Ensure lyophilized powder is shipped with ice packs and stored at -20°C upon receipt.
- Assess Supplier: Prefer manufacturers with GMP certification and at least 5 years of peptide production history.
- Test Small Batch: Order a 100mg sample for in-house purity and bioactivity validation before bulk commitment.
Core Product Advantages
GHRP-6 offers distinct benefits over competing peptides. Its high purity (≥98%) ensures minimal batch-to-batch variation, critical for reproducible research. The superior stability reduces degradation risks during transport and storage, lowering waste costs. Additionally, cost performance is optimized through bulk pricing tiers (e.g., $15–25 per gram for 100g+ orders), supported by dedicated technical support for formulation and assay troubleshooting.
Frequently Asked Questions
Q1: What is the difference between GHRP-6 and GHRP-2 in terms of stability?
GHRP-6 demonstrates 18% higher stability in serum at 37°C over 72 hours compared to GHRP-2, due to its D-amino acid configuration that resists enzymatic cleavage. This makes GHRP-6 preferable for long-term experiments.
Q2: How should I verify the quality of a GHRP-6 batch from a new supplier?
Request a third-party COA with HPLC purity ≥98%, MS confirmation of molecular weight, and endotoxin levels <1 EU/mg. Cross-reference the batch number with the manufacturer's database and perform an in-house solubility test in sterile water.
Q3: Can GHRP-6 be used in cosmetic formulations?
Yes, GHRP-6 is supplied as a research chemical for cosmetic studies. Typical formulations use 0.1–0.5% concentration in topical serums. Always verify local regulations, as it is not approved for human cosmetic use in all jurisdictions.