Melanotan 2 Peptide Purity Specs Manufacturing Guide

Core Molecular Specs & Product Technical Index

Melanotan 2 peptide is a synthetic cyclic tridecapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH), designed exclusively for advanced research and laboratory applications. This peptide consists of 13 amino acids with a molecular weight of approximately 1024.2 g/mol, featuring a lactam bridge that confers enhanced conformational stability compared to linear peptide analogs. For B2B buyers in the cosmetic raw material and laboratory supply sectors, the core commercial value lies in its high-purity formulation, which enables reproducible experimental outcomes in controlled in vitro studies.

Our manufacturing standard mandates a minimum purity grade of 98% or higher, verified by reverse-phase high-performance liquid chromatography (RP-HPLC) analysis. The product is supplied as a lyophilized white powder, ensuring optimal solubility in sterile water or bacteriostatic water for injection-grade research preparations. Storage requirements dictate that the peptide must be kept at -20°C in a desiccated, light-protected environment to maintain structural integrity over extended periods. Testing protocols adhere to national industry standards including USP <797> for compounding and ISO 9001:2015 quality management systems.

• Purity Grade: ≥98% by HPLC analysis, with batch-specific certificates of analysis (CoA) provided
• Molecular Weight: 1024.2 g/mol, confirmed by mass spectrometry (MS)
• Peptide Content: Typically 70-85% net peptide content, balanced with counterions for stability
• Endotoxin Levels: <1.0 EU/mg, ensuring suitability for sensitive in vitro assays
• Solubility: Freely soluble in water at 1-2 mg/mL, with pH adjustment recommended for optimal reconstitution

According to a 2023 industry report by Grand View Research, the global peptide synthesis market is projected to reach USD 62.3 billion by 2030, with high-purity research peptides like melanotan 2 accounting for a significant share due to increasing demand for standardized raw materials in cosmetic formulation development and laboratory studies.

Manufacturing Flow & Strict Quality Control System

The production of high-grade melanotan 2 peptide begins with rigorous raw material screening, where all amino acid derivatives and coupling reagents are sourced from GMP-certified suppliers with documented purity certificates. The synthesis employs solid-phase peptide synthesis (SPPS) using Fmoc chemistry on a rink amide resin, allowing for stepwise assembly of the peptide chain with controlled reaction conditions. After cleavage from the resin, the crude peptide undergoes multi-stage purification via preparative HPLC, targeting a purity threshold of 98% or higher. Each batch is then subjected to third-party testing certification, including HPLC, MS, and amino acid analysis, to confirm identity and purity. Long-term stability tests are conducted under accelerated conditions (40°C/75% RH for 4 weeks) to predict shelf life and storage requirements.

Main Certification Standards We Support

• cGMP Compliance: Manufacturing follows current Good Manufacturing Practices in ISO 9001:2015 certified facilities
• HPLC Analysis: Each batch includes a chromatogram showing purity peak at retention time 12.5-13.0 minutes
• Mass Spectrometry: ESI-MS or MALDI-TOF confirmation of molecular weight within ±0.5 Da tolerance
• Endotoxin Testing: LAL assay with results below 1.0 EU/mg for research-grade applications
• Stability Data: Accelerated stability studies with 24-month shelf life projection at -20°C storage

Main Commercial Application Scenarios

Our melanotan 2 peptide is positioned exclusively for controlled in vitro research and cosmetic raw material blending, with no claims for therapeutic or medical use. In cosmetic formulation development, it serves as a model peptide for studying melanin synthesis pathways in cell culture systems, aiding in the creation of topical formulations that modulate pigmentation. For laboratory research, it is utilized in receptor binding assays targeting melanocortin receptors (MC1R, MC3R, MC4R) to investigate signal transduction mechanisms. In compound raw material wholesale, it is supplied as a lyophilized powder for bulk distribution to research institutions and cosmetic ingredient manufacturers.

• Cosmetic Blending: Used in formulation studies at concentrations of 0.001-0.01% in topical creams or serums for in vitro skin model testing
• Laboratory Research: Applied in cell-based assays (e.g., B16-F10 melanoma cells) to evaluate melanogenesis modulation at 10-100 nM concentrations
• Compound Raw Material Wholesale: Bulk packaging in 10 mg, 50 mg, and 100 mg vials for distribution to certified research facilities

Comparison: melanotan 2 peptide VS Ordinary Low-Grade Peptide Raw Materials

Standard Buyer Selection Guide For Bulk Purchase

When sourcing melanotan 2 peptide for bulk purchase, B2B buyers must navigate common pitfalls such as impure synthesis by-products, unclear sourcing from unverified suppliers, and inconsistent peptide content across batches. Core screening criteria include verifying purity specifications through independent third-party HPLC analysis, confirming endotoxin levels for research-grade applications, and ensuring batch-to-batch consistency via supplier-provided stability data. Supplier qualification verification methods involve requesting GMP certificates, inspecting manufacturing facility audits, and reviewing customer references from peer research institutions.

Key Inspection Checklist Before Cooperation

• Request CoA: Verify that each batch includes HPLC chromatogram, MS confirmation, and endotoxin test results
• Check Storage: Confirm supplier maintains cold chain logistics for lyophilized peptide shipments
• Review Documentation: Ensure all certificates are current and match the batch number supplied
• Test Small Sample: Order a 10 mg sample for in-house HPLC verification before bulk commitment
• Evaluate Communication: Assess supplier responsiveness and technical support for formulation questions

Core Competitive Advantages Of Our melanotan 2 peptide

Our melanotan 2 peptide offers distinct competitive advantages in purity, stability, cost performance, and after-sales technical support. The purity level of ≥98% by HPLC ensures minimal by-product interference, which is critical for reproducible in vitro studies. Stability is enhanced through lyophilization and strict cold chain logistics, maintaining structural integrity for up to 24 months. Cost performance is optimized by offering bulk pricing tiers for 50 mg, 100 mg, and 500 mg quantities, reducing per-milligram costs by up to 40% compared to single-vial purchases. After-sales technical support includes access to formulation guidelines, reconstitution protocols, and batch-specific stability data, enabling researchers to integrate the peptide seamlessly into their workflows.

Frequently Asked Questions

Q: What is the standard purity specification for research-grade melanotan 2 peptide, and how is it verified?

A: The standard purity specification for research-grade melanotan 2 peptide is ≥98% as determined by reverse-phase high-performance liquid chromatography (RP-HPLC). Verification is conducted through a two-step process: first, analytical HPLC with UV detection at 214 nm to quantify the main peak area relative to total impurities; second, mass spectrometry (ESI-MS or MALDI-TOF) to confirm the molecular weight matches the theoretical value of 1024.2 g/mol. Each batch is accompanied by a certificate of analysis (CoA) that includes the chromatogram and mass spectrum for full transparency.

Q: How should melanotan 2 peptide be stored to maintain stability for long-term research use?

A: Melanotan 2 peptide should be stored as a lyophilized powder at -20°C in a desiccated, light-protected environment to prevent degradation. Avoid repeated freeze-thaw cycles by aliquoting the powder into single-use vials before storage. For reconstituted solutions, use sterile water or bacteriostatic water and store at 2-8°C for up to 7 days, or at -20°C for up to 30 days. Do not vortex or sonicate the solution, as mechanical stress can cause peptide aggregation. Always check the batch-specific stability data provided by the supplier for optimal storage conditions.

Q: What documentation should a reliable supplier provide for bulk melanotan 2 peptide purchases?

A: A reliable supplier should provide a complete documentation package including: a certificate of analysis (CoA) with HPLC purity percentage and chromatogram, mass spectrometry confirmation of molecular weight, endotoxin test results (LAL assay), peptide content percentage, and stability study summary. Additionally, request GMP compliance certificates, ISO 9001:2015 certification, and batch-specific manufacturing records. For international shipments, ensure the supplier provides material safety data sheets (MSDS) and customs documentation to facilitate smooth importation. Always verify that the documentation matches the batch number of the product received.